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Master Thesis

Étude de l’évolution du profil d’immunisation des patients hyper immunisés en attente de transplantation rénale

Abstract : Anti-HLA highly sensitized (HS) patients awaiting kidney transplantation benefit from national priority through the “HAP” program (HS with acceptable antigens). Maintaining this priority requires these patients have a serum tested with Single Antigen Flow Beads (SAFB) assays every 105 days in order to detect potential anti-HLA antibodies emergence and then prevent unexpected positive crossmatches. However, it seems that there is an imbalance between this high surveillance rate and the apparent stability of patient sensitization profiles. We aimed to assess the relevance of the quarterly biological follow-up of HS patients. We included 166 HS patients displaying at least 2 sera tested at 3-month intervals during their waiting period (S, the most recent, and S-3M). A median of 3 sera per patient were tested with SAFB. We also retrieved the occurrence of allogeneic and non-allogeneic immunological events for 75 patients. From the 357 serum pairs studied, only 0.7% of class I beads and 0.5% of class II beads crossed the unacceptable antigen threshold at the S serum [mean fluorescence intensity (MFI)≥2000] with a median MFI of 2963 and 2607, respectively. These beads corresponded to 248 antigens. Among them, 90% were above the threshold of the acceptable antigens (500
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https://dumas.ccsd.cnrs.fr/dumas-02973829
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Submitted on : Wednesday, October 21, 2020 - 12:13:28 PM
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Élodie Wojciechowski. Étude de l’évolution du profil d’immunisation des patients hyper immunisés en attente de transplantation rénale. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02973829⟩

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