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Master Thesis

Prévalence de l'atrophie des glandes meibomiennes chez le kératocône

Abstract : Purpose: to assess the prevalence of meibomian gland atrophy (MGA) in keratoconus patients. Setting: French Keratoconus national reference center, Bordeaux, France. Design: observational, monocentric, comparative case control study. Methods: Fifty-two Keratoconic eyes free of any surgical treatment (KC group) and fifty-two healthy eyes (NKC group) matched for age and gender, included from December 2018 to May 2019, underwent infrared meibography providing a meiboscore of MGA, scaled from 0 to 6. Lipid Layer Thickness (LLT) assessment using interferometry, Tear Break-Up Time (T-BUT) evaluated by a slit lamp examination and corneal OCT-based topography were also performed. Two different dry eye questionnaires (OSDI and SPEED) were filled in by the patients during the consultation. Additional data were collected on smoking, atopy, eye rubbing, contact lens wear, hormonal contraception and skin diseases. Results: the MGA in Keratoconus group was significantly higher than in control group (p<0.0001) with a mean meiboscore of 2.33 ± 1.48 and 0.92 ± 1.04 respectively. The mean lower eyelid meiboscore was 1.15 in keratoconus group vs 0.56 in control eyes (p<0.0001) and the mean upper eyelid meiboscore was 1.17 in keratoconus group vs 0.36 in control group (p<0.0001). Although there was no difference between the two groups regarding the LLT and the T-BUT; OSDI and SPEED test scores were significantly higher in KC group. Conclusion: keratoconus was associated with higher meibomian gland atrophy in this study. We emphasize that each Keratoconus patient should have a thorough examination of the ocular surface for signs of meibomian gland atrophy, as risk factors for dry eye, in a disease where eye rubbing was recognized as the main factor of progression. However, this preliminary study requires further studies with larger populations.
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Submitted on : Wednesday, October 21, 2020 - 2:55:14 PM
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Camille Morice. Prévalence de l'atrophie des glandes meibomiennes chez le kératocône. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02974016⟩



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