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Master Thesis

Hypoglycémies néonatales au CHU de Grenoble : une étude épidémiologique, aspects diagnostiques et thérapeutiques

Abstract : Objective: Differentiate the characteristics of children with transient hypoglycemia from those with persistent hypoglycemia and to identify possible risk factors. Design: Single-center case-control study. Location: Neonatal intensive care unit of Grenoble Alpes university-hospital. Patients: All newborns hospitalized in the department with a diagnosis of hypoglycemia between January 2016 and December 2018 were included. Children with unconfirmed diagnosis by the analysis of the record and those who died before the assessment were excluded. Results: 141 newborns were included (median postnatal age 259 days and 62% boys). Endocrine causes accounted for 74% of persistent hypoglycemia (PH). The presence of gestational diabetes in the mother is more frequently found in transient hypoglycemia (TH) (p =0.04). Risk factors such as prematurity (p = 0.005), macrosomia or SGA (p = 0.05) are more significantly present in the TH group. In the PH group, hypoglycemia was more severe, repeated and prolonged with a median duration of daily hypoglycemia of 7 days (p<0.001). Parenteral nutrition is also used more frequently in PH with median carbohydrate intakes of 18.0 g / kg / d [16.2-20] (p<0.001). Conclusion: This study shows that the profile of patients with HP is different from newborns with HT in terms of antenatal, neonatal, glycemic and medical care. Multiple simple criteria that may have a practical interest in identifying these patients before carrying out the medical check-up have been identified.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02975260
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Submitted on : Friday, October 23, 2020 - 10:05:58 AM
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Justine Descamps Suler. Hypoglycémies néonatales au CHU de Grenoble : une étude épidémiologique, aspects diagnostiques et thérapeutiques. Médecine humaine et pathologie. 2020. ⟨dumas-02975260⟩

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