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Master Thesis

Évaluation de la calprotectine comme facteur prédictif de rechute dans la polyarthrite rhumatoïde, lors de la décroissance des anti-TNF-alpha : une analyse post-hoc de l’étude STRASS

Abstract : The search for prognostic tools for the biological treatment tapering in patients with rheumatoid arthritis (RA), is a major challenge to decide their management. Our objective was to determine whether serum calprotectin concentration at baseline was associated with relapse within 18 months, in patients with rheumatoid arthritis in sustained remission during TNF-blocker tapering. We included patients presenting rheumatoid arthritis in sustained DAS28 remission, treated with Etanercept or Adalimumab, from the spacing randomization arm of STRASS study. Serum calprotectin concentration was assessed in patients by enzyme-linked immunosorbent assay at baseline. Disease activity was assessed every 3 months in each center by a rheumatologist. We assessed calprotectin concentration in 61 serums from patients of STRASS spacing arm, and 54 were included in per protocol analysis. No significant association was found in the per protocol analysis between the occurrence of at least one relapse within 18 months and baseline calprotectin concentration in spacing arm, (1309 ng/mL [879;2273] vs 1011 ng/mL [605;2112] in patients without relapse, p=0,1396). There was neither significant association between calprotectin concentration and at least one relapse in 18 months with multivariable model, (OR 0.99 (95% IC 0.99 to 1.00), p=0.929). Serum calprotectin concentration in patient with RA in remission with TNF-blocker does not predict relapse during Etanercept and Adalimumab tapering.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02977888
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Submitted on : Monday, October 26, 2020 - 10:28:54 AM
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Margot Clapasson. Évaluation de la calprotectine comme facteur prédictif de rechute dans la polyarthrite rhumatoïde, lors de la décroissance des anti-TNF-alpha : une analyse post-hoc de l’étude STRASS. Médecine humaine et pathologie. 2019. ⟨dumas-02977888⟩

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