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Master Thesis

Valeur prédictive de la spectroscopie par résonance magnétique sur le devenir neurodéveloppemental à l'âge de 2 ans chez une cohorte de nouveau-nés grands prématurés

Abstract : Despite progress in the survival of preterm children, their neurocognitive development remains a concern. Prematurity itself has a minor influence on neurodevelopmental fate, while per-natal factors have a predominant role in predicting their outcome. These factors include intrinsic factors such as intra-uterine growth restriction, or extrinsic factors such as antenatal cortico-therapy. Thus, the early identification (corrected term) of infants at high risk of neurodevelopmental disorder will allow appropriate and early support. However, precise prognostic markers are currently lacking to assess this risk. Magnetic resonance spectroscopy (MRS) objectively measures brain biochemistry in vivo. MRS is an imaging technique studying cerebral metabolism and variations in the concentration of metabolites, which is already used to characterize various pathologies such as anoxoischemia encephalopathy. Therefore, we believe that tissue metabolites can serve as important early diagnostic and prognostic biomarkers. But few studies have explored SRM over time to predict the fate of the very premature. The EPIPAGE2-EPIRMEX project allowed us to study by brain SRM the brain metabolites of 69 preterm infants, as well as their neurodevelopment at 2 years old
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https://dumas.ccsd.cnrs.fr/dumas-02987159
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Submitted on : Tuesday, November 3, 2020 - 3:56:21 PM
Last modification on : Thursday, November 5, 2020 - 3:24:51 AM
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  • HAL Id : dumas-02987159, version 1

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Marion Benoist. Valeur prédictive de la spectroscopie par résonance magnétique sur le devenir neurodéveloppemental à l'âge de 2 ans chez une cohorte de nouveau-nés grands prématurés. Gynécologie et obstétrique. 2020. ⟨dumas-02987159⟩

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