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Master Thesis

Survie et caractéristiques épidémiologiques des femmes atteintes de cancer pulmonaire à La Réunion

Abstract : Lung cancer is a frequent disease in the world, representing the first cause of death from cancer. Its incidence in the female population increases in metropolitan France and Reunion Island, the main risk factor remains tobacco. However environmental, genetic and hormonal factors appear to play a role in bronchial oncogenesis and the survival of affected women would be better than that of men. We studied the survival and characteristics of a retrospective cohort in Reunion Island, diagnosed with lung cancer between January 1, 2017 and December 31, 2018. 501 patients were included over the period including 166 women. The median overall survival was 23 months in women against 11 months in men (p <0.0005). Female sex has been identified as a good prognostic factor for overall survival (HR = 1.338; 95% CI = 1.007-1.778) regardless of disease stage. Women smoked less often than men 85.4% of them had adenocarcinoma, with more EGFR mutations than men, and their environmental exposures were lower. The female population of Reunion Island in our study therefore had better overall survival than the men. Smoking status, environmental exposures, histological and molecular characteristics varied by sex.
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https://dumas.ccsd.cnrs.fr/dumas-02995104
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Submitted on : Monday, November 9, 2020 - 6:12:16 AM
Last modification on : Tuesday, November 10, 2020 - 3:32:20 AM
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  • HAL Id : dumas-02995104, version 1

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Aurélie Kienlen. Survie et caractéristiques épidémiologiques des femmes atteintes de cancer pulmonaire à La Réunion. Sciences du Vivant [q-bio]. 2020. ⟨dumas-02995104⟩

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