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Master Thesis

Facteurs prédictifs et pronostiques dans les cancers du sein de phénotype luminal HER2 négatif traités par chimiothérapie néo-adjuvante

Abstract : The indications of neoadjuvant chemotherapy (NAC) for patients with estrogen receptor (ER)-positive HER2 negative early breast cancer (BC) remain controversial. We assessed the predictive and prognostic values of clinicopathological factors, stromal tumor infiltrating lymphocytes (sTIL), Magee equation 3 and IHC4 score in luminal Her2-negative BC treated by NAC. 221 patients with ER+HER2- early BC treated with NAC followed by surgery, were included in the study. Histological grade, sTIL, Magee equation 3, IHC4, Ki67 and Residual Cancer Burden (RCB) were determined on pre-treatment core biopsies and/or on surgical specimens. sTIL (HR = 5.030, CI95% [2.027-12.479], P = 0.0005) and grade (HR = 4.291, CI95% [1.783-10.324], P = 0.0011) were independent factors associated with RCB0/1. Independent prognostic factors for DRFI before chemotherapy were clinical stage (HR = 3.570, CI95% [1.990-6.404], P < 0.0001) and IHC4 (HR = 9.307, CI95% [3.251-26.640], P <0.0001) and after chemotherapy were Ki67 (HR = 5.816, CI95% [2.688-12.584], P < 0.0001), vascular emboli (HR = 2.484, CI95% [1.366-4.516], P = 0.0029) and grade (HR = 5.395, CI95% [1.164-24.995], P = 0.0312). These findings enhance the value of sTIL and grade as tools for aiding chemotherapy decision-making and IHC4 and Ki-67 for assessing prognosis in HER2-negative luminal BC.
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https://dumas.ccsd.cnrs.fr/dumas-03011576
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Submitted on : Wednesday, November 18, 2020 - 10:51:32 AM
Last modification on : Saturday, December 19, 2020 - 3:12:50 AM
Long-term archiving on: : Friday, February 19, 2021 - 6:53:07 PM

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  • HAL Id : dumas-03011576, version 1

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Chloé Delfour. Facteurs prédictifs et pronostiques dans les cancers du sein de phénotype luminal HER2 négatif traités par chimiothérapie néo-adjuvante. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03011576⟩

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