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Master Thesis

Effets de la vaccination grippe et pneumocoque sur l'incidence des effets indésirables immunologiques chez les patients sous immunothérapie pour un cancer broncho-pulmonaire de stade avancé

Abstract : Introduction: patients with non-small cell lung cancer (NSCLC) are at high risk of severe influenza and invasive pneumococcal infections. Literature data on the effect of influenza vaccination on the incidence of immune-related Adverse Events (irAEs) under immunotherapy are contradictory and there are no data on the effect of pneumococcal vaccination. Our objective is therefore to study the effect of influenza and pneumococcal vaccination on the incidence of irAEs in patients receiving immunotherapy for advanced stage NSCLC. Methods: patients included began immunotherapy between August, 2018 and April, 2019 (at the Bordeaux University Hospital. Vaccination status for influenza and pneumococcus was collected retrospectively, as was the occurrence of irAEs within 6 months, grade of severity, onset time and type of irAEs. Progression and survival data were also collected. Results: of the 80 patients included in the study, 31 were not vaccinated and 36 were vaccinated for influenza and pneumococcus. The overall incidence of irAEs was 25.0%. For double vaccinated patients it was 19.4% and 29.0% for unvaccinated patients (p = 0.401). The majority of irAEs were mild (88.0%) and occurred early. At 6 months, 64.5% of unvaccinated patients presented progression, compared to 52.8% for vaccinated patients (p = 0.009) and 51.6% of patients had died in the unvaccinated group compared to 27.8% (p = 0.039). Conclusion: the incidence of irAEs in patients receiving immunotherapy for advanced NSCLC has not increased when patients were vaccinated for influenza and pneumococcus. Vaccination appears to improve their response to immunotherapy.
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https://dumas.ccsd.cnrs.fr/dumas-03011931
Contributor : Médecine Ub <>
Submitted on : Wednesday, November 18, 2020 - 12:32:57 PM
Last modification on : Saturday, December 19, 2020 - 3:12:50 AM
Long-term archiving on: : Friday, February 19, 2021 - 7:23:48 PM

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Mathilde Monbrun. Effets de la vaccination grippe et pneumocoque sur l'incidence des effets indésirables immunologiques chez les patients sous immunothérapie pour un cancer broncho-pulmonaire de stade avancé. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03011931⟩

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