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Master Thesis

Évolution des consommations de soins et des coûts de prise en charge du cancer bronchique non à petites cellules

Abstract : Context: Incidence of non-small cell lung cancer (NSCLC) is high and this cancer has poor prognosis especially at metastatic stage. Few literature on long-term healthcare consumptions and associated costs for patients with advanced NSCLC treated with immunotherapies are available. The objective of this study is to describe the evolution of healthcare consumptions and associated costs for advanced NSCLC patients treated with nivolumab. Methods: Based on the national hospitals database (PMSI), a retrospective cohort composed of all patients initiating nivolumab for NSCLC between 2015 and 2016 was followed until December 2018. Healthcare consumptions and associated costs were described by trimester and by year. Trends were evaluated with Mann-Kendall test and evolution of healthcare consumptions and costs of patients alive 2 and 3 years after the initiation of nivolumab were evaluated with student test. Results: 10,452 patients were included. Mean number of hospital visits and hospitalizations per patient decreased over the follow-up (p<0.001). The major part of hospital visits was for one-day stays. Mean number of cumulative hospitalization days also decreased over the follow-up from 10.3 to 3.7 days (p<0.001). Mean cost per patient decreased from 20,000 euros at the first trimester to 7000 euros at last one. Conclusion: Healthcare consumptions and associated costs of patients initiating nivolumab decreased over the 3 years follow-up, suggesting a decrease in the intensity of care.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03012601
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, November 18, 2020 - 4:06:15 PM
Last modification on : Tuesday, November 24, 2020 - 4:00:19 PM

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  • HAL Id : dumas-03012601, version 1

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Valentine Grumberg. Évolution des consommations de soins et des coûts de prise en charge du cancer bronchique non à petites cellules. Sciences pharmaceutiques. 2020. ⟨dumas-03012601⟩

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