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Master Thesis

Brain and heart microvascular disease evaluated with cerebral MRI and myocardial perfusion entropy in SPECT, a neurovascular stroke patients' evaluation

Abstract : Introduction - Microvascular disease has been described in many organs, and is associated with poor outcome. The hypothesis of a diffuse organ damage is not answered, in particular the correlation of cerebral and myocardial microvascular dysfunction. This study is searching for a correlation between cerebral small vessels disease and coronary microvascular disease. Methods - We included 38 patients who had a stroke from atherothrombotic origin hospitalized in the CHUGA stroke unit w.ho were addressed to cardiology day hospital for a check-up including myocardial SPECT. Ali patients had a neurologie microvascular assessment using the Age Related White Matter Changes scale on MRI or CT scan. SPECT images were analysed with a software attributing an entropy score, corresponding the heterogeneity of pixels intensity of the myocardium. Coronary artery disease screening using SPECT was evaluated after a stroke. Results - We included 38 patients (mean age 64.2 years old +/- 10.9, 81% of men) who had a cerebral and myocardial microcirculation assessment after a stroke. No correlation has been found between ARWMC score and myocardial perfusion entropy, Spearman correlation -0, 10 p = 0,51. Among all patients, 27.1% had abnormal SPECT and 18.2% had a coronary angiogram, 9.1% had at least one severe coronary stenosis and 7.3% were revascularized, 80% of patients who underwent coronary angiogram had a treatment adaptation. Conclusion - No association was found between cerebral microvascular disease and myocardial perfusion heterogeneity, using myocardial perfusion entropy. Coronary artery disease screening in selected patients who had a stroke is efficient, leading to coronary revascularisation and treatments modifications.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03077739
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, December 16, 2020 - 3:49:03 PM
Last modification on : Friday, December 18, 2020 - 3:25:03 AM
Long-term archiving on: : Wednesday, March 17, 2021 - 7:37:00 PM

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  • HAL Id : dumas-03077739, version 1

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Victor Mathieu. Brain and heart microvascular disease evaluated with cerebral MRI and myocardial perfusion entropy in SPECT, a neurovascular stroke patients' evaluation. Human health and pathology. 2020. ⟨dumas-03077739⟩

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