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Master Thesis

Vitesse de traitement de l’information dans la Sclérose en Plaques : effets de la réhabilitation cognitivo-linguistique sur des performances de temps de réaction et sur les phénomènes de plasticité cérébrale sous-jacents chez 25 patients

Abstract : Cognitive problems are common in people living with multiple sclerosis (PwMS). Few studies evaluate the effectiveness of cognitive rehabilitation on IPS. Functional Magnetic Resonance Imaging (fMRI) can help to understand the mechanisms of brain plasticity related to the performance of IPS and their evolution after rehabilitation. Our ancillary study, based on a randomized, blinded, controlled clinical trial, aims to study the impact of a cognitive rehabilitation program on the performance of IPS in PwMS and to understand its mode of action by studying the phenomena of plasticity. The PwMS for which we had fMRI data were selected and randomized into 2 treatment groups of 50 individual sessions, 3 times a week: a REACTIV group benefiting from rehabilitation and a global management group. Two reaction time (RT) tasks, behavioural assessment and fMRI, were offered, pre- and post-treatment, as well as EDSS and self-questionnaires for fatigue, depression and anxiety. Statistical analyses comparing pre- and post-treatment RT were performed using the Mann Whitney and Wilcoxon tests. Twenty-five patients, 13 in the REACTIV group and 12 in the control group, and 22 controls matched for age, gender, and education level were included. Compared to controls, patients in the PwMS group had slower RT. RT scores on behavioural assessment and fMRI improved significantly only in the REACTIV group after rehabilitation. The fMRI analyses could not be finalized following Covid-19. Pre- and post-rehabilitation cognitive results on single RT tasks show potential for improvement in IPS while maintaining the quality of responses in the PwMS who underwent specific rehabilitation compared to those who underwent global management.
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https://dumas.ccsd.cnrs.fr/dumas-03085203
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Monday, December 21, 2020 - 4:05:04 PM
Last modification on : Wednesday, January 27, 2021 - 3:12:40 AM

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  • HAL Id : dumas-03085203, version 1

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Inès Dassy. Vitesse de traitement de l’information dans la Sclérose en Plaques : effets de la réhabilitation cognitivo-linguistique sur des performances de temps de réaction et sur les phénomènes de plasticité cérébrale sous-jacents chez 25 patients. Sciences cognitives. 2020. ⟨dumas-03085203⟩

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