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Master Thesis

L'impact du trouble de stress post-traumatique sur le craving en addictologie

Abstract : Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) are common comorbid conditions that are associated with more severe profile and worse clinical outcomes. Several main causal hypothesis have been developed to explain this high co-occurence, particularly the "self-medication", "high risk" and "dual diagnosis" models. Craving is defined as "the overwhelming urge to use a substance or a rewarding behavior although we don't want to". Craving has a triple interest in clinical practice including diagnosic, prognosic and therapeutic aspects. Given its central role in relapse vulnerability, craving is now considered as a key element of addictive disorders. The aim of this thesis was to assess the interactions between post-traumatic stress disorder and craving in individuals with substance addiction. We conducted a search in PubMed for published studies. Inclusion criteria were all clinical studies in humans examining the link between post-traumatic-stress-disorder and craving among individuals with addiction diagnosis. The screening retrieved 106 published studies, and 11 were included in the present review. Results showed that, among individuals with comorbid conditions, exposure to traumatic memories could trigger substance craving. Exposure to cue-related trauma and cue-related substance had an additive effect on craving intensity. Studies in daily life showed that daily variation of traumatic symptoms intensity was predictive of craving fluctuation. Finally, negative affects seemed to mediate the relationship between traumatic symptoms and craving. These results were concordant with the self-medication model and underscored the need to develop more integrated approches of this dual disorder for diagnosic et therapeutic purpose.
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Submitted on : Monday, December 21, 2020 - 4:32:48 PM
Last modification on : Wednesday, January 27, 2021 - 3:12:40 AM


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  • HAL Id : dumas-03085272, version 1



Fabien Renaud. L'impact du trouble de stress post-traumatique sur le craving en addictologie. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03085272⟩



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