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Master Thesis

Development of a new right ventricle evaluation technique using a gamma camera cadmium-zinc-telluride

Abstract : Right ventricular function is recognized as an important prognostic marker in heart failure. Objective of this study was to develop a new technique for analyzing right ventricle using a gamma camera CZT in tomoventriculography. lncluded patients were admitted to cardiology unit for a multimodal assessment of right ventricle. Then, cardiac magnetic resonance, radionuclide ventriculography and three dimensional echocardiography were performed within 15 days. Relationships between the continuous variables were assessed using Spearman's correlation analysis. Agreement was assessed by Bland-Altman analysis. A p-value < 0.05 was considered as statistically significant for all the analyses. A total of 21 patients were included. Mean RVEF values between three modalities were similar with no statistical differences (51.4 ± 8.7% for CMR, 48.2 ± 10.5% for isotopie ventriculography; p = 0.17 and 49.6 ± 7.9% for 30 TTE; p = 0.17). Correlations were good (for isotopie ventriculography: r = 0.72, p < 0.0001 , for 30 TTE: r = 0.64, p < 0.001 ). Bland-Altman analysis showed small mean difference in both cases (-3.6 ± 5.9 % for isotopie ventriculography and -2.7 ± 5.3 % for 30 TTE). There were no statistical differences between end systolic volumes obtained by CMR (70.5 ± 32 ml) and isotopie ventriculography (78.0 ± 33.2 ml; p = 0.59) and between 30 TTE (64.1 ± 29.5 ml; p = 0.59) and CMR. There were no statistical differences between end diastolic volumes obtained by CMR (143.4 ± 43.1 ml) and isotopie ventriculography (147.5 ± 41.7 ml; p = 0.65) and between 30 TTE (125.2 ± 46.2 ml; p = 0.65) and CMR. Bland-Altman analysis showed a systematic difference between CMR and 30 ETT (-18.9 ± 17.3 ml). Radionuclide ventriculography with CZT gamma camera appears to be an effective method for evaluating RV function 30 TTE appears also as an effective method.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03087034
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Wednesday, December 23, 2020 - 11:34:00 AM
Last modification on : Wednesday, January 6, 2021 - 3:24:59 AM

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  • HAL Id : dumas-03087034, version 1

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Antoine Apert. Development of a new right ventricle evaluation technique using a gamma camera cadmium-zinc-telluride. Human health and pathology. 2020. ⟨dumas-03087034⟩

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