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Master Thesis

Valeur pronostique du volume métabolique chez les patients traités par immunothérapie pour un cancer broncho-pulmonaire non à petites cellules

Abstract : Background: Reliable predictive and prognostic markers are still lacking for patients treated with PD1- Inhibitors for non-small cell lung cancer (NSCLC). The purpose of this study was to investigate the prognostic and predictive values of different baseline metabolic parameters, including metabolic tumor volume (MTV), from 18F-FDG PET/CT scans in patients with NSCLC treated with PD1-Inhibitors.
Methods: Maximum and peak standardized uptake values, MTV and total lesion glycolysis (TLG) as well as clinical and biological parameters, were recorded in 75 prospectively included patients with NSCLC treated with PD1-Inhibitors. Associations between these parameters and overall survival (OS) were evaluated as well as their accuracy to predict early treatment discontinuation (ETD).
Results: A high MTV and a high TLG were significantly associated with a lower OS (p < 0.001). The median OS in patients with MTV above the median (36.5 cm3) was 10.5 months (95% CI: 6.2 - upper limit: unreached) while the median OS in patients with MTV below the median was not reached. Patients with no prior chemotherapy had a poorer OS than patients which had received prior systemic treatment (p=0.04). MTV and TLG could reliably predict ETD (ROC curve AUC = 0.76, 95% CI: 0.65-0.87 and 0.72, 95% CI: 0.62-0.84 respectively).
Conclusion: MTV is a strong prognostic and predictive factor in NSCLC patients treated with PD1-Inhibitors and can be easily determined from routine 18F-FDG PET/CT scans. MTV, could help to personalize immunotherapy and be used to stratify patients in future clinical studies.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03098234
Contributor : Bibliothèque Universitaire de Médecine Nice Connect in order to contact the contributor
Submitted on : Tuesday, January 5, 2021 - 4:42:00 PM
Last modification on : Saturday, April 17, 2021 - 3:12:58 AM

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2020NICEM056.pdf
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  • HAL Id : dumas-03098234, version 1
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David Chardin. Valeur pronostique du volume métabolique chez les patients traités par immunothérapie pour un cancer broncho-pulmonaire non à petites cellules. Médecine humaine et pathologie. 2020. ⟨dumas-03098234⟩

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