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Master Thesis

Étude naturaliste observationnelle sur les effets secondaires dissociatifs de l’Eskétamine dans la dépression résistante

Abstract : Depression is the third cause of disability worldwide. A third of patients don’t respond to classical antidepressants. Esketamine, the s enantiomer of Ketamine, is a new generation antidepressant with an action on the glutamate neurotransmission. However, it causes dissociative side effects in 27% of cases. These are of variable intensity, quite unusual in the common psychiatric practice and present various challenges in the patient management.
A cohort of eight patients has been followed throughout their induction phase with the Esketamine nasal spray. A screening of previous dissociative symptoms was evaluated with the Cambridge depersonalization scale (CDS) and it was compared with the dissociation score after treatment administration, measured with the clinician administered dissociative states scale (cadss).
A possible positive correlation was found between the scores CDS and Clinician administered dissociative states scale (CADSS), mostly for the first two treatment sessions with a predominant depersonalization component, though without a statistical significance. The mean cadss score was calculated at 15.6. This pilot study reflects the possibility of predicting the outcome of dissociative side effects after Esketamine administration if patients have presented similar symptoms six months prior treatment. Esketamine dissociative side effects might have a different profile than those of racemic Ketamine. further work is needed on these effects because they might impede treatment access and have an abuse potential and also because they might be targeted by specific psychotherapy interventions that can have an overall improvement on patient management.
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Master Thesis
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Contributor : Bibliothèque Universitaire de Médecine Nice <>
Submitted on : Monday, January 18, 2021 - 5:05:22 PM
Last modification on : Saturday, July 17, 2021 - 3:19:50 AM


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  • HAL Id : dumas-03114019, version 1


Stefan-Claudiu Vasile. Étude naturaliste observationnelle sur les effets secondaires dissociatifs de l’Eskétamine dans la dépression résistante. Médecine humaine et pathologie. 2020. ⟨dumas-03114019⟩



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