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Master Thesis

Les pancréatites aiguës en réanimation pédiatrique : étude rétrospective monocentrique multi-sites française

Abstract : Background: acute pancreatitis (AP) incidence has increased dramatically over the past years. New guidelines in 2018 were recently published in order to standardize the definition and management of AP. The aim of this study is to describe the management of children that were diagnosed with AP from the pediatric intensive care unit (PICU) in two French hospitals. Methods: this retrospective cohort study included children aged under 18 years old, who were admitted to the PICU of Robert-Debré hospital and Trousseau from 2006 to 2018 with a discharge diagnosis of AP. Data collected included management, severity and outcomes. We have also obtained data on clinical, biological and radiological presentation. Results: sixty patients were included, the median age was 8 [5-14] years and 75% had a co-morbidity mainly hematologic (26/60). Most of the AP were moderate (52%) or severe (45%). Hemodynamic failure was the main reason for PICU admission requiring a median fluid resuscitation of 56 ml/kg complemented by a median intravenous fluid therapy of 4 [2-5] ml/kg/h during the first 24 hours. Fasting has been instituted to 59 patients (98%) for a median of 4 [1-6] days, 54 patients (90%) received parenteral nutrition and 18 patients (30%) received enteral nutrition. Antibiotic therapy was given to 53 patients (88%) including 13% for curative therapy. The median length of stay in PICU was 4 [2-6] days. The mortality rate was 13%. Conclusion: this is the first French study which precisely described the management of patients with AP in PICU. It highlighted the differences with the new international guidelines. This study could improve the management of PA in PICU.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03129049
Contributor : Université Paris Descartes - Scd <>
Submitted on : Tuesday, February 2, 2021 - 4:05:50 PM
Last modification on : Wednesday, May 19, 2021 - 3:23:21 AM

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Elsa Amouyal Chouraqui. Les pancréatites aiguës en réanimation pédiatrique : étude rétrospective monocentrique multi-sites française. Médecine humaine et pathologie. 2019. ⟨dumas-03129049⟩

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