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Master Thesis

Is post-stroke depression associated to brain imaging parameters?

Abstract : Background and purpose: the depression is a common complication after stroke, which has a negative impact on the rehabilitation and the recovery. Some behavioral findings suggest that post-stroke depression (PSD) could be a reactional phenomena, an interpretation that would predict no relationship with a specific brain area. This point, which remains debated, has never been investigated by modern technics of brain imaging analyses on a cohort including an adequate number of individuals to exclude false negative results. This was the objective of the present study. Methods: it is an ancillary study from the DOBRAS (Determinants of Balance Recovery After Stroke) cohort, in which participants were regularly and systematically assessed on 30 (± 3) (D30) and 60 (± 3) (D60) days after stroke. The depression was assessed by the Aphasic Depression Rating Scale (ADRS) a specific tool quantifying PSD, regardless aphasia (scores from 0 to 32, cut off egal or over 11). Brain imaging were analyzed on Magnetic Resonance Imaging (MRI) around 2 months after stroke (Nagaraja et al., 2020). We sought the relationship between PSD and three brain imaging parameters: structures affected by the stroke (Voxel-based Lesion Symptom Mapping (VLSM)), stroke volume (number of voxels) and white matter hyperintensities (WMH) (assessed by the Fazekas scale). Results: a total of 126 individuals were analyzed. Their median age was 65.9 [58.1-72.4] years and 85 (67%) males. They had been mostly assessed on D30 (n=70, 55%). Among them 53 (42%) were depressive. The median ADRS score was 10 [6-15]. Depression and its severity were associated to the existence of WMH (p=0.011), but not with stroke volume (p=0.619), not any specific areas. Conclusion: PSD must be particularly detected in case of WMH. This absence of specific brain structure related advocates for the reactional hypothesis of PSD.
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Master Thesis
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Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, February 15, 2021 - 11:44:53 AM
Last modification on : Thursday, February 18, 2021 - 3:19:20 AM


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  • HAL Id : dumas-03141412, version 1


Marie-Adeline Siegerth. Is post-stroke depression associated to brain imaging parameters?. Human health and pathology. 2020. ⟨dumas-03141412⟩



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