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Master Thesis

Évaluation de l’impact sur l’adaptation précoce de l’antibiothérapie de la technique d’antibiogramme rapide sur milieu solide gélosé Mueller-Hinton Rapide (MHR)

Abstract : Antimicrobial resistance continues to rise in the world. They are more and more complex and unpredictable, increase the risk of therapeutic mismatch and the mortality of patients. In this context, the culture agar Mueller Hinton Rapid (MHR, i2a) provides a quick antibiotic susceptibility results from blood culture or urinalysis in 6 to 8 hours in order to optimize the antibiotic therapy. The object of this study was to evaluate their impact on the early antibiotic therapy adaptation for patients treated for bloodstream infection or urinary tract infections. A prospective study has been realized. The antibiotic susceptibility tests from urinary samples and positive blood cultures with Enterobacteriaceae and S. aureus have been seed in MHR agar. The antibiotic susceptibility results were transmitted to the antimicrobial stewardship team. The antibiotic susceptibility results and the antibiotic therapy adaptation's delay were collected and retrospectively compared. For bloodstream infections, 163 patients were included and compared with 167 patients. The average therapy adjustment time was 7h (+/-2h30) versus 18h (+/-3h40) (p<0,001). For urinalysis, 107 patients were included and the average therapeutic adjustment time was 7h (+/-1h30). In conclusion, the culture agar MHR allowed an early antibiotic therapy adaptation. The technic is not expensive and could be routinely used. In order to be efficient, It would need to be paired with an antimicrobial stewardship team.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03144222
Contributor : Université Paris Descartes - Scd <>
Submitted on : Wednesday, February 17, 2021 - 2:21:19 PM
Last modification on : Thursday, September 2, 2021 - 3:09:13 AM

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  • HAL Id : dumas-03144222, version 1

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Julien Diep. Évaluation de l’impact sur l’adaptation précoce de l’antibiothérapie de la technique d’antibiogramme rapide sur milieu solide gélosé Mueller-Hinton Rapide (MHR). Médecine humaine et pathologie. 2019. ⟨dumas-03144222⟩

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