Skip to Main content Skip to Navigation
Master Thesis

Mise en place d’un logigramme de validation biologique des biomarqueurs pour la maladie d’Alzheimer. Place du dosage du peptide ß-amyloïde1-40

Abstract : Alzheimer’s disease is the first cause of dementia in the world, and the role of biology in the diagnosis remains uncertain. Nowadays, 3 biomarkers are commonly dosed in cerebrospinal fluid (CSF): ß-amyloid 42 (Aß42), total TAU (t-tau) and phosphoryled tau (p-tau). Our goal was to build a flowchart for biological validation in each situation with 1 or 2 positive biomarkers, with the possible help of a 4th biomarker (ß-amyloid 40); and to integrate the ATN classification (Amyloid, phosphoryled Tau, Neurodegeneration). We collected the results of 1368 biomarker assays carried out between January 2016 and May 2020. We compared their general characteristics according to the biomarker profile, the value of the Aß42/Aß40 ratio and the value of the Aß40 peptide itself. We also had the clinical information collected before and after the lumbar puncture for the 321 patients seen at the CMRR of the Bordeaux University Hospital in order to analyze the impact of these assays on diagnosis. This work shows the importance of biology by including physiopathology in the diagnosis process. Thanks to these results we concluded for 70% with « AD » or « no AD ». Clinicians mainly follow the conclusion of the lumbar puncture for the diagnosis. These promising results confirm the importance of biomarkers to help clinicians for AD diagnosis. However, consensus is needed to clarify the place of 4th biomarkers and also for threshold values of Aß42/Aß40 ratio and Aß40 itself.
Complete list of metadata

https://dumas.ccsd.cnrs.fr/dumas-03148907
Contributor : Médecine Ub Connect in order to contact the contributor
Submitted on : Monday, February 22, 2021 - 3:58:25 PM
Last modification on : Saturday, February 27, 2021 - 3:10:59 AM
Long-term archiving on: : Sunday, May 23, 2021 - 6:59:59 PM

File

Med_spe_2020_Rio.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-03148907, version 1

Collections

`

Citation

Benjamin Rio. Mise en place d’un logigramme de validation biologique des biomarqueurs pour la maladie d’Alzheimer. Place du dosage du peptide ß-amyloïde1-40. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03148907⟩

Share

Metrics

Record views

53

Files downloads

111