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Master Thesis

Rôle de GATA6 dans l’homéostasie de la partie supérieure du follicule pilo-sébacé humain et dans la physiopathologie de l’acné

Abstract : Although acne vulgaris is the most common human inflammatory skin disease, its pathogenic mechanisms remain incompletely understood. It is a disease of the upper part of the pilo-sebaceous unit which is made of ducts (infundibulum, junctional zone, sebaceous ducts) and of sebaceous glands. GATA6 is expressed in the upper pilosebaceous unit of normal human skin and is down regulated in acne. GATA6 controls keratinocyte proliferation and differentiation to prevent the hyperkeratinisation of the epidermal infundibulum, which is the primary pathological event in acne. When overexpressed in immortalised human sebocytes, GATA6 triggers a junctional zone and sebaceous differentiation program whilst limiting lipid production and cell proliferation. It modulates the immunological repertoire of sebocytes, upregulating PD-L1 and IL10, and controlling their ability to respond to Cutibacterium acnes. GATA6 expression contributes to the therapeutic effect of retinoic acid, the main treatment for acne. In a human 3D sebaceous organoid model, GATA6-mediated down-regulation of the infundibular differentiation program is mediated by induction of TGFß signalling. We conclude that GATA6 is a key regulator of homeostasis in the upper pilosebaceous unit and an actionable target in the treatment of acne.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03184126
Contributor : Université Paris Descartes - Scd <>
Submitted on : Monday, March 29, 2021 - 11:24:21 AM
Last modification on : Friday, September 3, 2021 - 3:32:56 AM

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  • HAL Id : dumas-03184126, version 1

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Bénédicte Oules. Rôle de GATA6 dans l’homéostasie de la partie supérieure du follicule pilo-sébacé humain et dans la physiopathologie de l’acné. Médecine humaine et pathologie. 2019. ⟨dumas-03184126⟩

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