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Master Thesis

Antécédents d'allergies et survenue de tumeurs du système nerveux central dans la cohorte Agrican

Abstract : Central nervous system tumors are heterogeneous and rare pathologies, with often poor prognosis. Their incidence is increasing in industrialized countries, raising suspicion of the role of environmental and occupational factors, including pesticides. Conversely, some factors such as allergies could have a protective effect, but the underlying mechanisms are not clearly identified. In France, the AGRICAN study (AGRIculture and CANcer), including 180,000 individuals affiliated to the Mutualité Sociale Agricole, was initiated in 2005 in order to study their health, in particular the occurrence of cancers related to occupational exposures and medical history. The objective of this thesis was to explore the associations between the history of allergies and the existence of tumors of the central nervous system among the AGRICAN cohort, based on the analysis of 500 cases of tumors, and self-report of allergic symptoms (asthma, rhinitis and/or eczema). Risks were calculated for tumors overall, and separately for gliomas and meningiomas, then by stratification according to work on a farm or to live in a farm in infancy. Our work showed tendencies towards elevations of risk in the presence of allergies, less pronounced in people who worked on a farm. A tendency for a decreased risk of glioma was observed in people with rhinitis, and a decreased risk of meningioma in those with eczema. These analyzes could be continued by considering more precisely agricultural exposures.
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Submitted on : Wednesday, April 21, 2021 - 2:17:50 PM
Last modification on : Thursday, May 13, 2021 - 3:18:16 AM
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  • HAL Id : dumas-03204352, version 1



Sarah Rousseau. Antécédents d'allergies et survenue de tumeurs du système nerveux central dans la cohorte Agrican. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03204352⟩



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