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Master Thesis

La chromoblastomycose en Guyane : épidémiologie et évolution des pratiques depuis 1950

Abstract : Introduction. Chromoblastomycosis (CBM) is a rare implantation mycosis in tropical and subtropical countries. There are few therapeutic studies. Material and methods. We realized a monocentric retrospective study about CBM in french Guiana, between 1950 and 2018. We analized data about clinic, paraclinic, demographic, treatment and evolution features. Results. There was 21 patients, 18 men and 3 women, average age was 59. Cutaneous lesions appeared 5 years and 7 months before, in average. Cases were from all parts of the territory, the cumulated annual incidence was 0.47 cases per 100 000hbts per year. 14 of 16 patients had risk activities. Cutaneous lesions were most commonly found on the lower limbs with symptoms like pruritus, pain and limitation for 6 cases over 14. The more the lesions was chronic, the more they were severe. Every documented cases were secondary to Fonsecaea pedrosoi. Surgery allowed total remission for 2 patients. Systemic treatments duration was more than 4 months with 31.7% cure rate but 50% relapse. The most efficient treatments were itraconazole, terbinafine and flucytosine, alone or in association. Tolerance was good. Conclusion. CBM is easy to diagnose and treatment or more efficient if used at an early stage of evolution. Actualtherapeutics are poorly effective despite long duration. This disease should be better known et studied to be better treated.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03210294
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Submitted on : Tuesday, April 27, 2021 - 8:59:15 PM
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Thibaut Muller. La chromoblastomycose en Guyane : épidémiologie et évolution des pratiques depuis 1950. Dermatologie. 2019. ⟨dumas-03210294⟩

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