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Master Thesis

Effect of a multimodal strategy for prevention of nosocomial influenza

Abstract : A multimodal strategy to prevent nosocomial influenza was implemented in 2015-2016 in our institution. Three modalities were implemented in all units: promotion of vaccination among healthcare workers, epidemiologic surveillance and communication campaigns. Units receiving a high number of patients with influenza implemented 2 additional modalities: improvement of diagnosis capacities and systematic face mask use. The main objective was to assess the effectiveness of the strategy for reducing the risk of nosocomial influenza. A retrospective study was conducted over 5 epidemic seasons (2014-2015 to 2018-2019) including all adult patients hospitalized with a positive influenza virological test at Grenoble Alpes University Hospital. The weekly number of nosocomial influenza cases was analyzed by Poisson regression and incidence rate ratios (IRR) were estimated. A total of 1555 stays were included. There was no significant difference between the 5 influenza epidemic seasons in the units implementing only 3 measures. In the units implementing the 5 measures, there was a significant reduction of nosocomial influenza over the last 3 epidemic seasons compared to the 2014-2015 epidemic season (IRR=0.39, 95%CI=0.19–0.81 in 2016-2017; IRR=0.49, 95%CI=0.24–0.99 in 2017-2018; IRR=0.48, 95%CI=0.23–0.97 in 2018-2019). Our data mainly suggested that the application of the strategy with 5 modalities, including systematic face mask use and rapid diagnosis, seemed to reduce by half the risk of nosocomial influenza. Further data, including medico-economic studies, are necessary to determine the opportunity of extending these measures at a larger scale.
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Master Thesis
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Submitted on : Monday, May 3, 2021 - 4:25:10 PM
Last modification on : Wednesday, May 5, 2021 - 3:23:33 AM
Long-term archiving on: : Wednesday, August 4, 2021 - 7:40:19 PM


  • HAL Id : dumas-03215981, version 1



Meghann Gallouche. Effect of a multimodal strategy for prevention of nosocomial influenza. Human health and pathology. 2020. ⟨dumas-03215981⟩



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