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Master Thesis

Risk factors of infections associated with antibiotic resistant microorganisms in patients with high risk neutropenia in a French hematology center

Abstract : Risk factors of documented infection with bacteria with significant antibiotic resistance in oncohematology (BSAROH) in high risk febrile neutropenia following chemotherapy are unclear in center with low antibiotic resistance level and no prophylaxis by fluoroquinolones. We included patients hospitalized for neutropenia > 7days and < 0.1G/L from December 2015 to June 2019 in a French hematology center. Three hundred and fifteen patients were included, for a total of 659 hospitalizations, half of them suffered from acute myeloid leukemia (165/315, 53.2%). A microbiological documentation was obtained in 191 (31.2%) of 612 hospitalizations with fever, including 187 (14.2%) with a BSAROH. Three hundred and twenty seven (53.4%) of febrile episode were fever of unknown origin. In multivariate hierarchic analysis, only age (Hazard ratio (HR) for 5 years=1.02 [1.00-1.04], p=0.02) and travel in foreign country within last 3 months (HR=3.58 [1.59-8.04], p=0.002) were associated with BSAROH. Antibiotic exposure, colonization with BSAROH, history of colonization with BSAROH, prior hospitalization and prior intensive care unit admission within 3 months were not significantly associated with a BSAROH onset. In center with low antibiotic resistance level, classical risk factors of BSAROH are not discriminant.
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https://dumas.ccsd.cnrs.fr/dumas-03217924
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Submitted on : Wednesday, May 5, 2021 - 11:09:28 AM
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  • HAL Id : dumas-03217924, version 1

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Baptiste Moisdon-Delapierre. Risk factors of infections associated with antibiotic resistant microorganisms in patients with high risk neutropenia in a French hematology center. Human health and pathology. 2020. ⟨dumas-03217924⟩

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