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Master Thesis

Évaluation des effets tératogènes et du taux de transmission materno-fœtale de la dengue en cours de grossesse : étude rétrospective

Abstract : Background : Dengue is the most prevalent arboviruses in the world. Despite its recent worlwide spread, its consequences on the fetus during pregnancy are still poorly assessed. The main purpose of our research was firstly to study the teratogenic effects of the dengue virus and secondly to measure the rate of maternal-fetal transmission (MFT) of dengue. Method : We carried out a retrospective study in the level III maternity unit of the Saint Pierre University Hospital Center, in Reunion Island (France) between January 1, 2019 and January 31, 2021, including pregnant patients who presented a biologically confirmed, clinical dengue. They benefited from specialized ultrasound monitoring and umbilical cord sampling during childbirth. Results : In our cohort of 215, 179 patients (83.3%) had ultrasound follow-up and 186 patients (86.5%) gave birth at the Saint-Pierre University Hospital Center. We observed 21.2% ultrasound abnormalities (38/179) of which 15.0% (27/179) could be related to an infectious fetopathy: 20 cases of small for gestationnal age (SGA) (11.1%) including 9 cases of intrauterine growth restriction (IUGR) (5.0%), 1 case of intrahepatic calcification (0.6%), 1 case of hepatomegaly (0.6%), 3 cases of brain abnormalities (1.8%) and 1 case of hydramnios (0.6%) without vertical transmission of the virus for these cases. The rate of MFT transmission of dengue in our study is 4.8%, with no cases of neonatal dengue. Conclusion : The dengue virus does not appear to present a teratogenic effect, however the slightly higher rate of SGA / IUGR in our cohort as well as the rate of MFT of dengue virus during pregnancy requires further studies on larger number of patients.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03218912
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Submitted on : Thursday, May 6, 2021 - 7:51:14 AM
Last modification on : Tuesday, October 19, 2021 - 5:56:43 PM
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  • HAL Id : dumas-03218912, version 1
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Luna Lemoine. Évaluation des effets tératogènes et du taux de transmission materno-fœtale de la dengue en cours de grossesse : étude rétrospective. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03218912⟩

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