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Master Thesis

Dynamics of anti-HBS antibody decay in vaccinated people living with HIV/AIDS: a long-lasting response

Abstract : Hepatitis B virus vaccination is recommended for people living with HIV/AIDS (PLWHA); we aimed to investigate anti-hepatitis B surface antibody (HBsAb) persistence over time. Design. Retrospective monocentric study of anti-HBs antibodies in PLWHA. Methods. We included PLWHA with at least two measurements of HBsAb between 2001 and 2018, excluding subjects positive for anti-HBc antibody or HBs antigen. We analyzed variations between two successive measurements if the first was >10 mUI/mL, unless HBV vaccination was performed between measurements, or if the increase between two dates was >100 mUI/mL (suggesting unrecorded vaccination). Results. We analyzed 887 pairs of successive titrations in 287 patients. The interval between samples was <10 months for 23.9%, 10-14 months for 43.6%, 15-27 months for 18.3%, and >27 months for 14.2%. Mean and median monthly decreases in anti-HBs titer were 2.6±10 mUI/mL and 0.29 mUI/ml, respectively. This monthly decay represents 0.7±3% (mean) or 0.6% (median) of the initial titer. Antibody decay was not associated with CD4+ T cell nadir, age, gender, or cytomegalovirus serostatus. The absolute value of monthly decay was positively correlated with the initial antibody titer, unlike the relative value. In 169 patients with HBsAb titer of >100 mUI/mL, median time to titer of <100 mUI/mL was 80 months for those with an initial HBsAb titer between 100-500 mUI/mL; this level was not reached for most of those with >500 mUI/mL. Conclusions. In vaccinated PLWHA, anti-HBs antibody titer decrease is low. It may be not necessary to measure it more than every 3-4 years, and even longer intervals in those with titer >500 mUI/mL.
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Master Thesis
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Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, June 9, 2021 - 10:26:24 AM
Last modification on : Friday, June 11, 2021 - 3:19:58 AM


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  • HAL Id : dumas-03254757, version 1


Alice Tomio. Dynamics of anti-HBS antibody decay in vaccinated people living with HIV/AIDS: a long-lasting response. Human health and pathology. 2021. ⟨dumas-03254757⟩



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