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Master Thesis

Embolisation artérielle prostatique dans l’hypertrophie bénigne de prostate : comparaison des microsphères et d’un mélange Glubran/lipiodol

Abstract : Objectives: Prostate artery embolization (PAE) is a promising alternative to surgery to treat lower urinary symptoms due to benign prostatic obstruction (BPO). PAE is mostly performed using microspheres as embolization agents. Our aim was to evaluate the feasibility, side effects and short-term performance of n-butyl cyanoacrylate glue (NBCA) compared with microspheres for PAE. Methods: This Institutional Review Board-approved, single-center, retrospective, cohort study included consecutive patients undergoing PAE from September 2017 to January 2020. Age, medical history, previous treatment, pre- and post-PAE prostatic volumes and International Prostate Symptom Scores (IPSS) were systematically analysed. Procedural duration, dosimetry, immediate and delayed complications were recorded. The main judgment criteria were the absolute and relative changes in IPSS at 3 months. Statistical analyses comprised unpaired t-tests, Wilcoxon tests, Chi-2 tests, uni- and multi-variate linear regression. Results: Sixty-two patients were recruited (median age: 65.9 years). Thirty-two were treated with microspheres and 30 with NBCA. Average procedure duration, scoping duration and received doses were significantly lower in the NBCA group (P=0.0011, 0.0001, and 0.0001, respectively). Immediate complications were all benign and there were no significant differences between the two groups (4/32 [12.5%] with microspheres versus 7/30 [23.3%] with NBCA, P=0.4335), nor for delayed complications (P=1). No association was found between the PAE techniques and the absolute change in IPSS (-10.2 ± 7.9 with microspheres versus -9.5 ± 7.6 with NBCA, P=0.7157). Conclusion: PAE using NBCA instead of microspheres is a safe and feasible endovascular treatment for symptomatic BPO, with an acceptable success rate and a low complication rate.
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https://dumas.ccsd.cnrs.fr/dumas-03270740
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Submitted on : Friday, June 25, 2021 - 10:42:17 AM
Last modification on : Friday, July 9, 2021 - 3:48:02 AM
Long-term archiving on: : Sunday, September 26, 2021 - 6:31:24 PM

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  • HAL Id : dumas-03270740, version 1

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Étienne Salet. Embolisation artérielle prostatique dans l’hypertrophie bénigne de prostate : comparaison des microsphères et d’un mélange Glubran/lipiodol. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03270740⟩

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