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Master Thesis

Sonoelastography to assess muscular stiffness among older adults and its use for the diagnosis of sarcopenia: a systematic review

Abstract : Background: structural changes susceptible to modify its stiffness have been reported in sarcopenic muscle. Sonoelastography is an accessible and non-radiating imaging technic allowing quantification of elastic properties of the tissue. We performed a systematic review of the literature to investigate whether sonoelastography can be a reliable method to assess sarcopenia in older patients. Methods: we search Medline, Google Scholar, Scopus, SpringerLink and Science direct from January 1st, 1990 up to April 1st, 2020. Three independent review authors assessed trial eligibility, extracted the data and assessed risk of bias. We intended to learn which types of elastography have been tested, the repeatability of such measures and if they have been compared to the currently accepted diagnostic method. Results: ten studies met the inclusion criteria. Most followed a cross-sectional design with young and older adults’ subgroups. Gastrocnemius, rectus femoris and vastus intermedius appeared the most. Nine of included studies used shear wave elastography and one-strain elastography. Passive elastic constant(k) was significantly greater in sarcopenic versus healthy subjects after passive stretching (124.98 ± 60.82 vs. 46.35 ± 15.85, p=0.004), but even in non- sarcopenic patients age was responsible for about 45.5% of variance in SWV. Amongst ten included articles, four reported higher stiffness in older adults’ muscles, two in contrary- lower, and four found no significant difference. Conclusions: due to the substantial heterogenicity of actual data, we could not conclude on the potential usefulness of elastography to assess sarcopenia. Further studies are needed, including larger sample of older patients, and using standardized and reproducible protocol.
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Master Thesis
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Submitted on : Friday, September 3, 2021 - 2:06:18 PM
Last modification on : Tuesday, December 7, 2021 - 4:10:58 PM
Long-term archiving on: : Saturday, December 4, 2021 - 7:17:27 PM


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  • HAL Id : dumas-03334054, version 1


Ewa Magdalena Janczyk. Sonoelastography to assess muscular stiffness among older adults and its use for the diagnosis of sarcopenia: a systematic review. Human health and pathology. 2020. ⟨dumas-03334054⟩



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