Skip to Main content Skip to Navigation
Master Thesis

L’étude en IRM des enfants atteints de la maladie de Ménière suggère une physiopathologie différente des adultes

Abstract : Background and Purpose: The aim of this study is to conduct a clinic-radiological exploration of a population referred in the context of pediatric Meniere's disease. Magnetic Resonance Imaging (MRI) scans were performed using a delayed acquisition to collect information about the presence of endolymphatic hydrops and vestibular aqueduct ossification. Added to a descriptive analysis of imaging findings, we proposed a correlation study of the clinical factors associated with imaging biomarkers. Material and method: We conducted a multicenter retrospective study on a pediatric population (<18 years) referred for Meniere's disease, for whom an MRI using the delayed protocol was performed between November 2014 and June 2021. All patients underwent MRI with 3DFLAIR sequences performed 4h after intravenous Gadolinium injection. We collected in the institutional picture archiving and communication system (PACS) and electronic patient medical record, the potential presence of endolymphatic hydrops on MRI, their location (cochlear/ saccular/ canalar) and side added to the vestibular aqueduct degree of ossification. We have also recorded the age, sex, clinical symptoms and personal history of inner ear malformations and family history of Meniere’s Disease for each patient. Results: The study database consisted of 9430 MRI, including 43 MRI scans performed on patients aged 7 to 17 years at the time of the MRI scan. The pediatric population included 27 girls (63%) and 16 boys (37%). The prevalence of hydrops in this population was of 35% (15 children). 7 patients had cochlear hydrops, 11 had saccular hydrops and 5 had canalar hydrops. 9 hydrops were unilateral on the left inner ear, 4 hydrops were found as bilateral, no hydrops was found on the right inner ear in isolation. Of the patients with hydrops, 4 were male (27%) and 11 were female (73%). 4 patients presented with a family history of Meniere’s disease, and their MRIs revealed the presence of hydrops in all of them, including 3 bilateral ones. The vestibular aqueduct was never ossified in all 43 patients. Conclusion: The 3DFLAIR sequences performed 4h after injection of Gadolinium allow the detection of hydrops in children with Meniere's disease in 35% of the patients, with a different distribution of the hydrops location from those found in the general population. The bilateral pathological involvement in case of a family history of Meniere’s disease and the absence of ossification of the vestibular aqueduct suggest a different pathophysiology from adults.
Document type :
Master Thesis
Complete list of metadata

https://dumas.ccsd.cnrs.fr/dumas-03383416
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Monday, October 18, 2021 - 3:49:18 PM
Last modification on : Thursday, October 21, 2021 - 4:34:29 AM

File

2021GRAL5169_grangette_eve_dif...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-03383416, version 1

Citation

Eve Grangette. L’étude en IRM des enfants atteints de la maladie de Ménière suggère une physiopathologie différente des adultes. Médecine humaine et pathologie. 2021. ⟨dumas-03383416⟩

Share

Metrics

Record views

38

Files downloads

27