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Master Thesis

Sémiologie et pronostic de l’infection congénitale à cytomégalovirus après primo-infection maternelle du second trimestre de la grossesse

Abstract : Congenital CMV is a major cause of neurological and sensory impairment in children. Objective - Description of the symptomatology and radiological semiology of infected fetuses in the second trimester of pregnancy; assessment of the prevalence and neonatal and long-term prognosis of fetuses with intrauterine growth restriction (IUGR) and small for gestational age birth weight (SGA). Material and Method - Monocentric retrospective study including patients referred for CMV seroconversion in the second trimester of pregnancy with a positive CMV viral load in amniotic fluid and a known neonatal outcome. Results - 111 fetuses had positive amniocentesis for CMV, 33 of them after second trimester seroconversion (29.7%). 21.2% of the fetuses were symptomatic at birth but none were long-term symptomatic. Radiological semiology, essentially composed of extracerebral signs, was a prognostic factor for birth symptomatology in univariate analysis. In utero, fetuses with IUGR were significantly more symptomatic at birth than eutrophic fetuses (64.7% vs. 12.1%, p<0.001) but not in the long term. Among infected fetuses, PAG had no more symptoms at birth and in the long term than eutrophic children (30.8% vs. 20.3%, p=0.73 and 23.1% vs. 19.9%, p=0.69 respectively). Conclusion - the prognosis for infected children in the second trimester is good. The long-term prognosis of hypotrophic children antenatally or at birth is equivalent to that of eutrophic children.
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Master Thesis
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  • HAL Id : dumas-03457624, version 1

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Nathalie Cornet. Sémiologie et pronostic de l’infection congénitale à cytomégalovirus après primo-infection maternelle du second trimestre de la grossesse. Médecine humaine et pathologie. 2019. ⟨dumas-03457624⟩

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