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Master Thesis

Étude des facteurs de risque prédictifs de complications post opératoires après cystectomie pour cancer

Abstract : Background : Radical cystectomy is the gold standard treatment for muscle-invasive bladder cancer. It is associated with a considerable risk of postoperative morbidity. In this study, we assessed the preoperative characteristics to determine risk factors for post operative complications. Method : This monocenter retrospective study included 205 patients undergoing radical cystectomy from January 2015 through October 2020. Preoperative characteristics of the patients were recorded for the study and post operative complications within 90 days separate in early complications (during hospitalisation) and late complications (after discharge and before 90 days) were graded according to the modified Clavien-Dindo classification (high grade for III-V). Univariate and multivariate logistic regression analyses were done to identify predictive factors of patients developing complications. Results : Any early complications were registered for 161 patients (69,8%). In univariate analyse elevated risk of complications was significantly associated with Charlson’s score≥3. BMI≥35kg/m2 and antithrombotic therapy were significantly associated with early high grade complications. Cardiovascular comorbidity were significant risk factors for high grade late post operative complications (18,5%). In multivariate analysis, BMI≥35kg/m2 and antithrombotic therapy were independant risk factors for high grade early complications. Conclusion : Risk factors for post operative complications depends with patient’s comorbidity. Identification of theses risk factor could be interesting to reduce the morbidity with implementation of pre authorization protocols.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03462730
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Submitted on : Thursday, December 2, 2021 - 8:43:20 AM
Last modification on : Saturday, December 11, 2021 - 3:32:44 AM

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  • HAL Id : dumas-03462730, version 1

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Antoine Le Quellec. Étude des facteurs de risque prédictifs de complications post opératoires après cystectomie pour cancer. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03462730⟩

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