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Master Thesis

Nanomédicaments et voie orale, formulation basse énergie de nanocapsules lipidiques

Abstract : Nowadays, nanomedicines are fast-growing due to the advantages they offer in the field of galenic formulation. The objective of this work is the formulation of lipid nanocapsules (LNCs) through a low-energy emulsification method, and which can encapsulate a model molecule, beta-carotene. 2 process of phase inversion have been chosen: one of these processes is based on temperature cycle (phase inversion temperature or PIT), the other rests on a composition variation, with, particularly, the quantity of water brought to the system (phase inversion composition or PIC). The LNCs obtained by these 2 processes are analyzed (by dynamic light scattering) and the underlying mechanisms are studied by different techniques, especially conductimetry, tensiometry, and rheology. Nanovectors are of particular interests in the case of an oral administration. However, the gastro-intestinal tract presents many barriers to the absorption of active ingredients. Stability studies in biomimetic media are also mentioned.
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Master Thesis
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Submitted on : Monday, December 6, 2021 - 2:19:04 PM
Last modification on : Saturday, December 18, 2021 - 3:53:36 AM


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  • HAL Id : dumas-03467269, version 1


Laura Hervieu. Nanomédicaments et voie orale, formulation basse énergie de nanocapsules lipidiques. Sciences pharmaceutiques. 2021. ⟨dumas-03467269⟩



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