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Master Thesis

Étude de l'incidence, des caractéristiques clinico-biologiques et du pronostic des atteintes sévères du virus de la grippe en réanimation entre 2017 et 2020

Abstract : Introduction: Influenza is a highly contagious acute respiratory disease with a seasonal course and a high mortality rate. Annual vaccination is an effective means of prevention, and the use of different therapies is well codified. Methods: We compared and analysed the incidence and clinico-biological characteristics of patients hospitalised in one of the four participating ICUs for severe influenza between 2017 and 2020. We also looked at prognosis and risk factors for mortality. Results: In our cohort, we found the known risk factors for severe influenza infection and a predominance of the H1N1 strain throughout the study. Bacterial superinfection remained the most frequent pre- and per-hospitalization complication followed by acute renal failure. All available treatment options were used, with no significant difference over the three periods. Our overall mortality rate was comparable to national data. And acute renal failure, a complication during the stay and high prognostic scores seemed to be in favour of excess mortality. Conclusion: Our study is of epidemiological interest to better understand influenza pathology and annual variations. However, the SARS-CoV2 pandemic has strongly impacted the rate of influenza infection and consequently the number of ICU patients.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03544418
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Submitted on : Wednesday, January 26, 2022 - 4:14:11 PM
Last modification on : Friday, January 28, 2022 - 3:35:20 AM

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Laura Bettane. Étude de l'incidence, des caractéristiques clinico-biologiques et du pronostic des atteintes sévères du virus de la grippe en réanimation entre 2017 et 2020. Médecine humaine et pathologie. 2021. ⟨dumas-03544418⟩

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