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Master Thesis

Devenir en FIV/ICSI de la population en échec d’insémination intra utérine

Abstract : Introduction: The primary objective was to review the IVF/ICSI outcome of the failed IUI population at Caen University Hospital from 01/01/2014 to 01/01/2020. The secondary objective was to establish prognostic factors of live birth in IVF/ICSI in this population of failed IUI. Methods: A monocentric retrospective study was performed, we included 195 couples managed in IVF/ICSI after having performed at least 2 IUIs without live birth. Data were collected on MEDIFIRST software. Results: 43% of couples with failed IUI obtained a live birth in IVF/ICSI. 71% of them obtained it on the first attempt. Good prognostic factors were the age of the woman, not smoking man, the FSH value and idiopathic infertility. Discussion: The highlighted for a successful IVF-ICSI after IUI failure are identical to those described in the literature for the whole population undergoing ART and do not explain the failure of IUI compared with IVF/ICSI management. Live birth is most often obtained on the first IVF/ICSI attempt, which proves that in these couples there are pre-existing anomalies of gametic interaction and probably of oocyte or sperm quality not detected on the initial infertility work-up. As idiopathic infertility has a favourable prognosis in IVF after IUI failure, it seems important to carry out further explorations in women and in men after the failure of 2 IUI and before continuing. Women with reduced ovarian reserve have a poor prognosis in IUI but also in IVF, oocyte donation seems to give the best chances of live birth.
Document type :
Master Thesis
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Submitted on : Monday, February 14, 2022 - 4:26:37 PM
Last modification on : Saturday, April 2, 2022 - 3:38:36 AM
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  • HAL Id : dumas-03573377, version 1


Alice Lecacheur. Devenir en FIV/ICSI de la population en échec d’insémination intra utérine. Médecine humaine et pathologie. 2021. ⟨dumas-03573377⟩



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