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Master Thesis

Étude observationnelle des prescriptions des IPP chez les personnes de 65 ans et plus en officine

Abstract : PPIs are indispensable medicines in many indications. The absence of immediate adverse effects has, however, led to significant exposure in the general population. In many cases, these treatments are used over very long periods of time. For several years, some studies have shown the increased risk of bone fractures, digestive infections, or kidney failure... In 2019, the HAS issued its opinion on the use of PPIs in France and some guidelines on the main observed misuses. Efforts to prescribe and de-prescribe these drugs must be made in a multi-professional manner with the aim of maintaining an optimal benefit/risk ratio for the patient. The study examined the pattern of prescribing and use of PPIs in people 65 years of age and older in informal settings. The majority of patients use PPIs over the long term, for non-MA or unwarranted indications. The hygieno-dietetic rules are an asset in the management of digestive pathologies, including dyspepsia and GERD allowing, in many cases, not to use a treatment or to allow the cessation of a PPI. Some countries, such as Canada, are more advanced in re-evaluating existing treatments, including PPIs. Deprescription algorithms are proposed and many tools are made available to re-evaluate the treatment by IPP in patients using them long term. PPIs are treatments that are more than proven to be effective. Like all drugs, they expose the patient to a potential risk if their use is not reasoned and justified. It is therefore necessary that the treatment be re-evaluated over time and deleted if necessary. Indeed, the benefit/risk ratio must be a primary objective, without losing the chance of improving the patient’s health.
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Master Thesis
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Submitted on : Thursday, February 17, 2022 - 9:29:10 AM
Last modification on : Friday, February 18, 2022 - 3:37:25 AM
Long-term archiving on: : Wednesday, May 18, 2022 - 6:27:00 PM


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  • HAL Id : dumas-03578138, version 1



Alexandra Mas. Étude observationnelle des prescriptions des IPP chez les personnes de 65 ans et plus en officine. Sciences du Vivant [q-bio]. 2022. ⟨dumas-03578138⟩



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