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Master Thesis

Profil évolutif des dilatations aortiques dans l'artérite à cellules géantes

Abstract : Objectives: To analyse the aortic dilation’s (AD) follow-up in giant-cell-arteritis (GCA), and to identify factors associated with a progression of AD. Patients and method: In a cohort of 532 patients, 34 patients present with AD and are devised intro three groups according to their progression: fast (FP), slow (SP) et not-progressive (NP). Their follow-up is studied through a single center retrospective study; factors associated with a rapid progression are identified through a multivariate analysis. Results: The FP patients are older (p=0,003), and present atherosclerotic carotid disease (p=0.02) or cerebrovascular (p=0.03) than other group. No difference was demonstrated regarding the presentation to diagnosis, aortitis, like immunosuppressants use or ACG the follow-up. There is great heterogeneity in the monitoring of AD. Patients received monitoring equivalent to 1.19 imaging/year [0.35-6.06]. 6 patients presented a surgical indication, and 4 patients are operated. Among the 8 patients who presented with a cardiovascular complication, 3 patients presented an aortic dissection or aneurysm rupture. In multivariate analysis, the predictors of rapid progression were age >75 years, (Hazard ratio: 25 [range: 5.70-985]), existence of >2 cardiovascular risk factors (HR=3.5 [1.55-403.8]) and initial weight loss (HR=11.76 [1.30-388]). Conclusions: GCA patients with AD and the factors of rapid progression such as age>75 years and cardiovascular risk factors should be closely monitored. The heterogeneity of follow up suggests that a larger prospective study be carried out to establish recommendations.
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Master Thesis
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Submitted on : Thursday, February 17, 2022 - 5:26:38 PM
Last modification on : Saturday, April 2, 2022 - 3:38:36 AM
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  • HAL Id : dumas-03579042, version 1


Sophie Gallou. Profil évolutif des dilatations aortiques dans l'artérite à cellules géantes. Médecine humaine et pathologie. 2021. ⟨dumas-03579042⟩



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