HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Master Thesis

Profil évolutif des dilatations aortiques dans l'artérite à cellules géantes

Abstract : Objectives: To analyse the aortic dilation’s (AD) follow-up in giant-cell-arteritis (GCA), and to identify factors associated with a progression of AD. Patients and method: In a cohort of 532 patients, 34 patients present with AD and are devised intro three groups according to their progression: fast (FP), slow (SP) et not-progressive (NP). Their follow-up is studied through a single center retrospective study; factors associated with a rapid progression are identified through a multivariate analysis. Results: The FP patients are older (p=0,003), and present atherosclerotic carotid disease (p=0.02) or cerebrovascular (p=0.03) than other group. No difference was demonstrated regarding the presentation to diagnosis, aortitis, like immunosuppressants use or ACG the follow-up. There is great heterogeneity in the monitoring of AD. Patients received monitoring equivalent to 1.19 imaging/year [0.35-6.06]. 6 patients presented a surgical indication, and 4 patients are operated. Among the 8 patients who presented with a cardiovascular complication, 3 patients presented an aortic dissection or aneurysm rupture. In multivariate analysis, the predictors of rapid progression were age >75 years, (Hazard ratio: 25 [range: 5.70-985]), existence of >2 cardiovascular risk factors (HR=3.5 [1.55-403.8]) and initial weight loss (HR=11.76 [1.30-388]). Conclusions: GCA patients with AD and the factors of rapid progression such as age>75 years and cardiovascular risk factors should be closely monitored. The heterogeneity of follow up suggests that a larger prospective study be carried out to establish recommendations.
Document type :
Master Thesis
Complete list of metadata

https://dumas.ccsd.cnrs.fr/dumas-03579042
Contributor : Ufr Santé Unicaen Connect in order to contact the contributor
Submitted on : Thursday, February 17, 2022 - 5:26:38 PM
Last modification on : Saturday, April 2, 2022 - 3:38:36 AM
Long-term archiving on: : Wednesday, May 18, 2022 - 7:36:20 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-10-14

Please log in to resquest access to the document

Identifiers

  • HAL Id : dumas-03579042, version 1

Citation

Sophie Gallou. Profil évolutif des dilatations aortiques dans l'artérite à cellules géantes. Médecine humaine et pathologie. 2021. ⟨dumas-03579042⟩

Share

Metrics

Record views

9