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Master Thesis

Réorganisation des aires motrices après un infarctus cérébral‎ : méta-analyse des études de neuro-imagerie fonctionnelle

Abstract : Over the two past decades, brain imaging studies have allowed to examine brain reorganization of motor areas after stroke. Nevertheless, the role of those patterns in relation to recovery remained to clarify. To address the time-related evolution at the level of the motor network and the functional relevance of those plastic changes in recovery, we performed an activation likelihood estimation voxel-based meta-analysis (MTA) of functional imaging studies investigating motor related brain activity after stroke. Of over 635 PubMed search results through April 2012, 24 studies (251 patients with upper-limb impairment and 145 healthy subjects) reported standardized whole-brain group coordinates were included. This MTA highlighted an additional activation of contralesional motor areas early after stroke, which tended to abate over time underlining a progressive restoration of the interhemispheric balance. Moreover, we showed an early reorganization of neural activity within SMA and ipsilesional motor cortex and a decrease of the activation in contralesional cerebellum was evidenced in stroke patients. A good recovery after stroke was associated with activation in SMA and ipsilesional motor cortex. In contrast, a bad recovery appeared to be linked with a cerebellum vermal activation which may be the reflect of behavioral compensatory strategies implicating the fastigio-thalamo-cortical loop and reticulo-spinal tract. Plastic changes within S1M1 appeared to be linked with a good recovery, suggesting a vicariant process. In conclusion, cerebral reorganization contributes to functional recovery after stroke. Functional imaging data can help to design predictive models of recovery.
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Master Thesis
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Submitted on : Wednesday, November 28, 2012 - 3:40:17 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Friday, March 31, 2017 - 4:47:41 PM


  • HAL Id : dumas-00758341, version 1
  • PPN : 165822902


Isabelle Favre. Réorganisation des aires motrices après un infarctus cérébral‎ : méta-analyse des études de neuro-imagerie fonctionnelle. Human health and pathology. 2012. ⟨dumas-00758341⟩



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