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Master Thesis

Intérêt du dosage couplé de la troponine I hypersensible et de la copeptine pour le diagnostic d'exclusion de SCA non ST+ chez les patients se présentant pour une douleur thoracique aux urgences

Abstract : Objectives : The aim of this study was to analyze of the performance of high sensivity cardiac troponin I(TnI hs) and Copeptin coupled assay as a mean to rule out a diagnosis of non-ST elevation myocardial infarction (NSTEMI) for patients admitted in emergency department (ED) because of chest pain. Methods : The study is prospective and carried out during emergency care. Coupled assay of Tni hs and Copeptin was carried out for 58 patients admitted in ED because of chest pain that had started less than 6 hours before and without ST-segment elevation on the electrocardiogram. In each case, the final diagnosis was given either by a cardiologist or two emergency physicians, blinded to the copeptin results. Results : NSTEMI was diagnosed in 6 patients. The sensitivity and the negative predictive value (NPV) of TnI hs alone and the coupled assay of TnI hs with copeptin were respectively 16,7% (95% Confidence Interval of 0,4-64,1) and 91,1% (CI95%=80,4-97) versus 50% (CI95%=11,8-88,2) and 92,3% (CI95%=71,1-98,4). Conclusion : The results of the study, however not statistically significant, tend to support the other studies carried out on the same topic. To run a meta analysis would enable to confirm the results and to put into common practice the use of Copeptin.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00819762
Contributor : Jean-Hugues Morneau <>
Submitted on : Thursday, May 2, 2013 - 11:54:25 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Tuesday, April 4, 2017 - 2:40:40 AM

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  • HAL Id : dumas-00819762, version 1

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Emilie Maubert. Intérêt du dosage couplé de la troponine I hypersensible et de la copeptine pour le diagnostic d'exclusion de SCA non ST+ chez les patients se présentant pour une douleur thoracique aux urgences. Médecine humaine et pathologie. 2013. ⟨dumas-00819762⟩

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