Exposition aux antibiotiques et risque d’obésité : revue systématique de la littérature

Abstract : Introduction : Obesity has become a public health concern. This disease affects more than 600 million people in the world, which leads to severe comorbidities. Causes are multifactorial. Recent studies raise questions about antibiotic effects on intestinal microbiota and the development of obesity. Objective : To investigate in the literature the association between antibiotic use and the risk of obesity in humans. Methods : This study is a systematic review of the literature. Six databases were explored to search English and French publications, between January 2006 and March 2017. Results : After selection, 12 articles were analyzed. Antibiotic exposure seems to have a long term impact on human metabolism. Weight gain appears to be more important if the exposure occurs early in life and repeatedly. This effect seems to be more pronounced in men. Conclusion : The sources of exposure to antibiotics are multiple. Use of the latter is to be associated to weight gain, through gut microbiota imbalance. Probiotics appear as a potential aid. Even if the analyzed studies have low level of evidence, these results lead to be vigilant. Antibiotic prescription should be reasoned, to limit the development of overweight and obesity.
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Master Thesis
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Submitted on : Friday, October 6, 2017 - 5:24:52 PM
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Laura Bottollier Curtet, Aude Server. Exposition aux antibiotiques et risque d’obésité : revue systématique de la littérature. Médecine humaine et pathologie. 2017. ⟨dumas-01612318⟩

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