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Master Thesis

Safety and long term efficacy of radiofrequency ablation for lung tumors

Abstract : Background: the purpose of this study was to evaluate the safety and long-term efficacy of radiofrequency ablation in lung tumors using small 17-gauge needles. Materials and methods: all patients with lung tumors treated using radiofrequency ablation performed with 17-gauge needles between June 2005 and October 2008, were enrolled in the study. All procedures were performed under general anesthesia. After RFA procedure, patients underwent clinical and imaging follow-up at regular intervals up to 10 years. Results: forty-two consecutive patients with 57 lung tumors including 5 patients with lung carcinoma, 19 patients with colorectal carcinoma metastasis and 18 patients with metastasis from other origin met the inclusion criteria. Median tumor size was 24.4 mm (range: 11-60 mm). Three patients (5.8%) presented with major complications including hemoptysis treated conservatively (n=2) and pneumothorax requiring chest tube placement (n=1). Univariate analysis demonstrated that a tumor diameter of 27.0 ± 7.5 mm vs 21.5 ± 5.1 mm was a predictive factor of progression (p=0.02). After 16.1 ± 8.7 months, lung-free and progression free survival were 46% and 41%, respectively. Median overall survival was 29.8 months (1.8 -154.4) and median overall survival without progression were 25.6 months. Overall survival rates at 1-, 2-, 3-, 4- and 5- years were 93%, 71%, 58%, 39% and 31%, respectively. Conclusion: radiofrequency ablation using small 17-gauge needles is a valuable treatment option of small size lung tumors (<27 mm) and is associated with a low rate of complications.
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Master Thesis
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Submitted on : Monday, April 15, 2019 - 2:35:33 PM
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  • HAL Id : dumas-02099993, version 1


Jean-Baptiste Sautiere. Safety and long term efficacy of radiofrequency ablation for lung tumors. Human health and pathology. 2018. ⟨dumas-02099993⟩



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