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Master Thesis

Application d’une nouvelle technique d’IRM (Transfert d’Aimantation inhomogène - ihMT) à la sclérose en plaques

Abstract : This study aimed at providing preliminary evidences for the potential of inhomogeneous Magnetization Transfer (ihMT), a new endogeneous myelin-specific MRI contrast, for multiple sclerosis (MS) by evaluating its sensitivity for the pathology along with its capacity to provide complementary information relative to standard MT when applied on a population of remitting-relapsing (RR) MS patients.
Materials and Methods Twenty-five RR MS patients (20/5 women/men, mean age 42/41 years) and 20 healthy volunteers (14/6 women/men, mean age 42/39 years) were enrolled in a prospective MRI research study, whose protocol included anatomical imaging, standard MT and ihMT imaging. MT/ihMT ratios (MTR/ihMTR) measured in brain normal appearing (NA) brain tissue and in MS lesions of patients were compared to values measured in control subjects. The potential association of MTR/ihMTR variations with the clinical score of patients was further evaluated.
Results MTR/ihMTR values measured in thalami, frontal, occipital and temporal white matter (WM) of MS patients were lower compared to those of controls (P<0.05). Mean ihMTR/MTR values measured in lesions were lower than that in NAWM (P<0.005).
Conclusion The sensitivity of the ihMT technique for MS was demonstrated by significant changes in ihMTR values in both demyelinated lesions and NA tissues of RR MS patients. Additionally, its capacity to provide complementary information relative to standard MT was illustrated by stronger correlations of ihMTR with the clinical disability.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02328027
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Submitted on : Wednesday, October 23, 2019 - 9:45:02 AM
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Élise van Obberghen. Application d’une nouvelle technique d’IRM (Transfert d’Aimantation inhomogène - ihMT) à la sclérose en plaques. Médecine humaine et pathologie. 2017. ⟨dumas-02328027⟩

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