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Master Thesis

Quantification du volume des hyper signaux T2 pulmonaires dans la mucoviscidose : étude préliminaire

Abstract : Background. Using MRI in cystic fibrosis (CF), pulmonary structures with high T2 signalintensity relate to inflammatory changes in the lung and bronchi. These areas of pathology can serve as imaging biomarkers. The feasibility of an automated quantification is unknown. Purpose. To quantify the MRI T2 high-signal-intensity lung volume (T2-HSV) and T2 volume-intensity product (VIP) using a black blood T2 radial turbo spin echo sequence in CF. Material and methods. Healthy participants and study participants with CF were prospectively enrolled between January 2017 and November 2017. All participants underwent a lung MRI protocol including T2- radial turbo spin echo sequence. Participants with CF also underwent pulmonary function tests (PFTs) the same day. Participants with CF exacerbation had repeat MRI after their treatment with antibiotics. Two observers supervised automated quantification of T2-HSV and T2-VIP independently and the average score was chosen as consensus. Statistical analysis used the Mann-Whitney test for comparison of medians, correlations used Spearman test, comparison of paired medians used Wilcoxon signed rank test and reproducibility was evaluated using the intraclass correlation coefficient (ICC). Results. In 10 healthy participants (21 (range: 18-27) years; 6 males) and 12 participants with CF (18 (9-40) years; 8 males), T2-HSV was equal to 0% and 4.1 (0.1-17) %, respectively and T2-VIP was equal to 0ms and 303 (39-1012) ms, respectively (p<0.001). In CF, T2-HSV or T2-VIP were associated with forced expiratory volume in 1 second percentage predicted (ρ -0.88 and ρ -0.94, respectively; p<0.001). In six participants with CF exacerbation and follow-up after treatment, a decrease in both T2-HSV and T2-VIP was observed (p=0.03). The intra and inter-observer reproducibility of MRI were very good (ICCs>0.99). Conclusion. In CF, automated quantification of lung MRI high-signal-intensity volume was reproducible and correlated with pulmonary function testing severity and improved after treatment for CF exacerbation.
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Submitted on : Wednesday, January 8, 2020 - 11:27:47 AM
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François Hocke. Quantification du volume des hyper signaux T2 pulmonaires dans la mucoviscidose : étude préliminaire. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02431916⟩



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