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Master Thesis

Troubles pigmentaires associés au psoriasis : étude de prévalence sur 459 patients du CHU du Bordeaux

Abstract : Background: pigmentation disorders occurring in psoriasis have received little attention in the literature. Objectives: to describe the prevalence of pigmentation abnormalities in psoriasis patients and their association with their demographic and clinical features. Methods: single-centre prospective study including consecutive patients consulting for psoriasis between february 2018 and march 2019. Demographic and clinical features of psoriasis and pigmentation abnormalities were recorded. Impact on quality of life (QoL) was assessed. Results: four hundred and fifty-nine patients were included. Pigmentation abnormalities occurred in 23.7% of patients (13.7% and 10% for hyperpigmentation or hypopigmentation, respectively). Pigmentation abnormalities developed at sites previously affected by psoriasis. Two patterns of hyperpigmentation were observed: homogeneous hyperpigmentation and lentiginous plaques. Unlike the absence of pigmentation abnormalities, hypopigmentation was significantly associated with a shorter course of treatment (p=0.0053) and negatively associated with PASI90 (OR: 0.28, CI 95% [0.10-0.72]) and age (OR: 0.96, CI 95% [0.93-0.99]). Hyperpigmentation was significantly associated with higher skin phototype (IV, V, VI) (OR: 3.99, CI 95% [1.60-10.00]). Overall, pigmentation abnormalities were not associated with impact on QoL. Limitations: single-centre study including patients with fair skin. Conclusion: pigmentary disorders in psoriasis patients are frequent, occur at sites of previously affected skin and should be considered by physicians.
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  • HAL Id : dumas-02496039, version 1

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Séverine Amico. Troubles pigmentaires associés au psoriasis : étude de prévalence sur 459 patients du CHU du Bordeaux. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02496039⟩

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