Skip to Main content Skip to Navigation
Master Thesis

Coxites au cours de la fièvre méditerranéenne familiale : étude de 130 hanches dont 6 nouvelles atteintes françaises

Abstract : Introduction: familial mediterranean fever (FMF) is a monogenic autoinflammatory disorder linked to mutations of MEFV. We performed a literature review about coxitis in FMF and reported seven new cases. Methods: five new patients with seven new coxitides were reported. We reviewed the literature on Pubmed from 1946 to 2018. Results: 138 coxitides were found in 35 articles from 1908 to 2017 including our new cases. 36% were bilateral (n=56). Mean age at onset was 19.4 years (n=42). In 48% of cases (n=66), patients had suffered from protractile arthitis (i.e. arthritis lasting longer than three weeks). 38% of coxitides were remittent, and 14% had a mechanical pain pattern. 15% (n=21) were associated with another possible causative disease: sacroiliitis (13.5%), ASASproven spondyloarthropathy (9.4%) and idiopathic juvenile arthritis (1.5%). 75% (n=103) of coxitides resulted in a chronic impairment, especially those with protractile arthritis (89% of impairment in this subgroup). Colchicine was often efficient for pain relief (9/13). However hip arthroplasties occured oftenly (n=54) at a young age (mean 28.4 years). Conclusion: Coxitis in FMF has a severe prognosis, especially in its protractile form. Its natural history is at high risk for arthroplasty at a young age.
Document type :
Master Thesis
Complete list of metadata
Contributor : MEDECINE UPC Connect in order to contact the contributor
Submitted on : Friday, March 12, 2021 - 3:05:56 PM
Last modification on : Monday, September 12, 2022 - 5:33:09 PM
Long-term archiving on: : Sunday, June 13, 2021 - 6:01:29 PM


Files produced by the author(s)


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License


  • HAL Id : dumas-02501349, version 1


François Rodrigues. Coxites au cours de la fièvre méditerranéenne familiale : étude de 130 hanches dont 6 nouvelles atteintes françaises. Médecine humaine et pathologie. 2018. ⟨dumas-02501349⟩



Record views


Files downloads