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Master Thesis

Tacrolimus pommade dans la prise en charge de la kérato-conjonctivite atopique

Abstract : Atopic keratoconjunctivitis is associated with eyelid eczema. It may require the use of local corticosteroids which if prolonged can be a source of ocular complications. Tacrolimus is an immunosuppressant used in cutaneous application in atopic dermatitis. The aim of this study was to measure the efficacy and tolerance of tacrolimus 0.1% ointment in palpebral application in atopic keratoconjunctivitis.
Materials and methods
This retrospective, single-center study was conducted between June 2014 and February 2017. Patients with atopic keratoconjunctivitis not controlled by first-line medical treatments were included. The primary endpoint was the evolution of functional signs as assessed by the NEI-VFQ25 and OSDI quality of life scores. Secondary endpoints were visual acuity and local corticosteroid use.
Among the 18 patients included, the mean age was 37.9 ± 16.8 years. The first follow-up visit was on average 68.3 ± 55.3 days after initiation of treatment. The NEI-VFQ25 score was significantly improved for seven of its sub-scores (p <0.05) and the mean OSDI decreased significantly from 52.3 ± 26.2 to 22.0 ± 27.0 (p <0.001) showing a decrease in eye discomfort. A significant reduction was observed in the number of patients using local corticosteroids. There was no significant change in visual acuity.
Tacrolimus ointment 0.1% in palpebral application appears to be an effective treatment for the management of atopic keratoconjunctivitis.
Document type :
Master Thesis
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Submitted on : Thursday, June 11, 2020 - 10:55:44 AM
Last modification on : Tuesday, June 16, 2020 - 3:23:40 AM


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  • HAL Id : dumas-02864596, version 1


Daniel Benaim. Tacrolimus pommade dans la prise en charge de la kérato-conjonctivite atopique. Médecine humaine et pathologie. 2019. ⟨dumas-02864596⟩



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