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Master Thesis

Reconstruction mammaire immédiate dans le cancer du sein et délai à la prise en charge adjuvante

Abstract : Objective: The objective of our study was to investigate the timeframe for adjuvant management of mastectomies and immediate breast reconstruction (IBR) by expander prosthesis, definitive prosthesis, or large back flap in breast cancer. Material and methods: This was a retrospective monocentric, case-control study conducted at the Grenoble University Teaching Hospital between September 2015 and January 2020. The primary endpoint was lateness in the initiation of adjuvant treatment defined as over 42 days between surgery and chemotherapy; over 56 days between surgery and radiotherapy in the absence of an indication for chemotherapy; and over 196 days between surgery and radiotherapy with adjuvant chemotherapy as recommended by the INCA. Results: we included 116 patients in the study, 52 in the IBR group (44.8%) and 64 in the mastectomy group (55.2%). There was no significant difference between the two groups for lateness in adjuvant management. Concerning delay for initiation of adjuvant treatment, we identified 9 risk factors, including smoking and preservation of areolar-nipple plate, which is significantly more present in the RMI group. There was no significant difference in the complication rate between the two groups. Conclusion: IBR does not delay adjuvant management compared to mastectomy, regardless of adjuvant therapy.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-02880300
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Submitted on : Wednesday, June 24, 2020 - 5:47:14 PM
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Alexandra Collarde. Reconstruction mammaire immédiate dans le cancer du sein et délai à la prise en charge adjuvante. Médecine humaine et pathologie. 2020. ⟨dumas-02880300⟩

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