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Master Thesis

Fiabilité des paramètres échocardiographiques chez des patients porteurs de ventricule droit systémique : étude prospective multicentrique

Abstract : Backgrounds: systemic right ventricle (RV) is a rare and complex form of congenital heart disease (CHD) with a prognosis related to RV dysfunction and impaired physical capacity. Routine follow-up relies on cardiac ultrasound, however the prognostic value of echocardiography parameters remains under debate. Real-life patient follow-up involves different ultrasound systems. We aimed to evaluate echocardiography parameters’ reliability in systemic RV, in terms of reproducibility, using a vendor-independent software, and prediction of physical capacity impairment. Methods: Adult patients with D-transposition of the great artery (d-TGA) or congenitally corrected TGA (cc-TGA) were included in this multicentre prospective study. Current ultrasound parameters were analysed using TomTec-Arena™ software. Intraclass correlation coefficients (ICC) assessed inter- and intraobserver reliability. Associations between the most reproducible echocardiography parameters and exercise capacity (peak VO2, VE/VCO2 slope) were explored. Results: A total of 47 patients were included in the study (85% d-TGA, median age 36.4 ± 8 years). Conventional and 2D strain echocardiography parameters indicated the existence of a RV dysfunction (TAPSE 12.8±3.1 mm; RV free wall longitudinal 2D strain 13.6±3.9 %). Good reproducibility (ICC>0.75) for both intra and interobserver variability was observed in 9 RV echocardiography parameters. Among them, the TAPSE and the RV free wall longitudinal 2D strain, using TomTec-Arena™ RV speckle tracking software algorithm, were associated with peak VO2 (r=0.4 and 0.26, respectively). Conclusion: Using a vendor-independent software, TAPSE and RV free wall longitudinal 2D strain were the mostreliable echocardiography parameters in this prospective study, which attempted to reflect real-life follow-up of patients with systemic RV.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03046475
Contributor : La Réunion Université <>
Submitted on : Tuesday, December 8, 2020 - 2:08:04 PM
Last modification on : Saturday, December 12, 2020 - 3:55:40 AM
Long-term archiving on: : Tuesday, March 9, 2021 - 7:26:57 PM

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  • HAL Id : dumas-03046475, version 1

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Victor Pommier. Fiabilité des paramètres échocardiographiques chez des patients porteurs de ventricule droit systémique : étude prospective multicentrique. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03046475⟩

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