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Master Thesis

Effets neurocomportementaux du lactate de sodium molaire dans un modèle animal de traumatisme crânien diffus

Abstract : Introduction: Traumatic brain injury (TBI) is a major health issue with high mortality and long term neurological sequelae. Developing neuroprotective therapies that improve the prognosis is a challenge. Hypertonic sodium lactate (HSL) treatment is emerging as a promising option for brain injury. Our objective is to evaluate the post-traumatic administration of HSL on behavioral deficits. Methods: Four groups of rats (n= 10 rats per group) were studied. TBI-Lactate and TBI-Saline received a continuous infusion of HSL and Saline respectively, during two hours, thirty minutes after "impact acceleration " TBI. Similarly, two Sham-operated groups with no TBI insult received either Saline or HSL. We measured cerebral edema by 7T MRI two hours after TBI, then the animals were woken up. Cognitive deficits were determined using an adhesive removal test and a Radial Maze test 7 and 14 days after TBI. Results: Among all groups, only one TBI-Saline rat died on Day 1. TBI-Lactate rats showed a trend towards reduced brain edema compared to TBI-Saline rats. TBI-saline rats remained 99 [73 - 134] s in the maze versus 176 [127 - 300] s for the TBI-Lactate group on Day 7 (p=0.04). Note that 40% of TBI-Saline rats did not pass the Radial Maze test on Day 7 and received the highest duration as score (300 s), while all TBI-Lactate animals succeeded. TBI-Lactate rats removed the 2 adhesives from their forelimbs faster than TBI-Saline rats, both on Day 7 (p=0.03) and Day 14 (p=0.02). Conclusion: Acute administration of hypertonic sodium lactate attenuates cognitive deficits 7 and 14 days after TBI and could be used as a neuroprotective drug for traumatic brain injured humans.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03087215
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, December 23, 2020 - 3:17:50 PM
Last modification on : Wednesday, January 6, 2021 - 3:25:39 AM

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Thibaud Crespy. Effets neurocomportementaux du lactate de sodium molaire dans un modèle animal de traumatisme crânien diffus. Médecine humaine et pathologie. 2018. ⟨dumas-03087215⟩

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