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Master Thesis

Molécules hybrides antiplasmodiales ciblant les parasites résistants à l’artémisinine

Abstract : Malaria, parasitic disease caused by Plasmodium spp. and transmitted by anopheles, is the deadliest parasitic disease in the world. Preventive measures combined with many available drugs allowed to reduce the impact of this disease since the 90s. Those advances are questioned for some years with the appearance of a resistance targeting artemisinin and its derivatives. Those derivatives, with other drugs of different therapeutic classes, form the artemisinin-based combined therapies, first line of treatment against malaria. The responsible mutated gene is Pfkelch13, highlighted on 2010. Since then, the resistance’s mechanism is known: in presence of an artemisinin derivatives, the parasite is able to enter a quiescent stage thus inducing an insensitivity to treatment. Some metabolic pathways are still actives in those quiescent parasites, making them interesting targets to kill resistant parasites. This document constitutes a review of the state of malaria. This review of the state allows to introduce medicinal chemistry works about the synthesis of hybrid compounds containing molecules targeting metabolic pathways that are still active in quiescents parasites.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03095482
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Submitted on : Monday, January 4, 2021 - 4:24:14 PM
Last modification on : Friday, February 12, 2021 - 3:29:22 AM
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  • HAL Id : dumas-03095482, version 1

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Romain Mustière. Molécules hybrides antiplasmodiales ciblant les parasites résistants à l’artémisinine. Sciences pharmaceutiques. 2020. ⟨dumas-03095482⟩

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