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Master Thesis

Identification des perturbateurs endocriniens dans les matières premières cosmétiques

Abstract : Endocrine disruption is a very sensitive subject. Substances that disrupt the hormonal system can come from multiple sources of exposure and raise concern for consumers and scientists, in particular because of the difficulty of their identification. Due to the ban of animal experimentation, the cosmetics industry cannot perform in vivo testing as described in the EFSA/ECHA guideline for identification of endocrine disruptors. The strategy developed in this report proposes a sequential approach and uses tests (QSAR, in silico, in vitro), which do not involved laboratory animals. These tests are more and more accepted and validated by regulatory authorities and are tools that can be used as part of the next generation risk assessment. However, the cosmetic industry will need additional models to be able to conclude on the endocrine disruption properties of substances. The study of endocrine disruptors is far from being finished despite the significant scientific advances this past few years.
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Master Thesis
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Contributor : Frédérique Gambade <>
Submitted on : Tuesday, January 5, 2021 - 9:33:15 AM
Last modification on : Friday, January 29, 2021 - 3:10:24 AM
Long-term archiving on: : Wednesday, April 7, 2021 - 9:23:28 AM


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  • HAL Id : dumas-03096656, version 1



Léna Theaux. Identification des perturbateurs endocriniens dans les matières premières cosmétiques. Sciences du Vivant [q-bio]. 2020. ⟨dumas-03096656⟩



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